Effects of compound stimulation of fluid shear stress plus ultrasound on stem cell proliferation and osteogenesis.

ABSTRACT: Bone tissue with strong adaptability is often in a complex dynamical microenvironment in vivo, which is associated with the pathogenesis and treatment of orthopedic diseases. Therefore, it is of great significance to investigate the effects of corresponding compound stimulation on cell behaviors. Herein, a fluid shear stress (FSS) plus ultrasound stimulation platform suitable for cell studies based on a microfluidic chip was constructed and bone marrow mesenchymal stem cell (BMSC) was chosen as a model cell. The proliferation and osteogenesis of BMSCs under the compound stimulation of FSS plus ultrasound in growth medium without any soluble induction factors were firstly investigated. Single FSS stimulation and static culture conditions were also examined. Results illustrated that s

SUBMITTER: Jing L 

PROVIDER: S-EPMC8634505 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature