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Local Microcircuitry of PaS Shows Distinct and Common Features of Excitatory and Inhibitory Connectivity.

ABSTRACT: The parasubiculum (PaS) is located within the parahippocampal region, where it is thought to be involved in the processing of spatial navigational information. It contains a number of functionally specialized neuron types including grid cells, head direction cells, and border cells; and provides input into layer 2 of the medial entorhinal cortex where grid cells are abundantly located. The local circuitry within the PaS remains so far undefined but may provide clues as to the emergence of spatially tuned firing properties of neurons in this region. We used simultaneous patch-clamp recordings to determine the connectivity rates between the 3 major groups of neurons found in the PaS. We find high rates of interconnectivity between the pyramidal class and interneurons, as well as features of pyramid-to-pyramid interactions indicative of a nonrandom network. The microcircuit that we uncover shares both similarities and divergences to those from other parahippocampal regions also involved in spatial navigation.

SUBMITTER: Sammons RP

PROVIDER: S-EPMC8634576 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature

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Local Microcircuitry of PaS Shows Distinct and Common Features of Excitatory and Inhibitory Connectivity.

Sammons Rosanna P RP Tzilivaki Alexandra A Schmitz Dietmar D

Cerebral cortex (New York, N.Y. : 1991) 20211101 1

The parasubiculum (PaS) is located within the parahippocampal region, where it is thought to be involved in the processing of spatial navigational information. It contains a number of functionally specialized neuron types including grid cells, head direction cells, and border cells; and provides input into layer 2 of the medial entorhinal cortex where grid cells are abundantly located. The local circuitry within the PaS remains so far undefined but may provide clues as to the emergence of spatia ...[more]

PMID: 34289029

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Project description:How the connectivity of cortical networks determines the neural dynamics and the resulting computations is one of the key questions in neuroscience. Previous works have pursued two complementary approaches to quantify the structure in connectivity. One approach starts from the perspective of biological experiments where only the local statistics of connectivity motifs between small groups of neurons are accessible. Another approach is based instead on the perspective of artificial neural networks where the global connectivity matrix is known, and in particular its low-rank structure can be used to determine the resulting low-dimensional dynamics. A direct relationship between these two approaches is however currently missing. Specifically, it remains to be clarified how local connectivity statistics and the global low-rank connectivity structure are inter-related and shape the low-dimensional activity. To bridge this gap, here we develop a method for mapping local connectivity statistics onto an approximate global low-rank structure. Our method rests on approximating the global connectivity matrix using dominant eigenvectors, which we compute using perturbation theory for random matrices. We demonstrate that multi-population networks defined from local connectivity statistics for which the central limit theorem holds can be approximated by low-rank connectivity with Gaussian-mixture statistics. We specifically apply this method to excitatory-inhibitory networks with reciprocal motifs, and show that it yields reliable predictions for both the low-dimensional dynamics, and statistics of population activity. Importantly, it analytically accounts for the activity heterogeneity of individual neurons in specific realizations of local connectivity. Altogether, our approach allows us to disentangle the effects of mean connectivity and reciprocal motifs on the global recurrent feedback, and provides an intuitive picture of how local connectivity shapes global network dynamics.

Dataset Information

Local Microcircuitry of PaS Shows Distinct and Common Features of Excitatory and Inhibitory Connectivity.

Publications

Local Microcircuitry of PaS Shows Distinct and Common Features of Excitatory and Inhibitory Connectivity.

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