High-Quality Genome-Scale Reconstruction of Corynebacterium glutamicum ATCC 13032.

ABSTRACT: Corynebacterium glutamicum belongs to the microbes of enormous biotechnological relevance. In particular, its strain ATCC 13032 is a widely used producer of L-amino acids at an industrial scale. Its apparent robustness also turns it into a favorable platform host for a wide range of further compounds, mainly because of emerging bio-based economies. A deep understanding of the biochemical processes in C. glutamicum is essential for a sustainable enhancement of the microbe's productivity. Computational systems biology has the potential to provide a valuable basis for driving metabolic engineering and biotechnological advances, such as increased yields of healthy producer strains based on genome-scale metabolic models (GEMs). Advanced reconstruction pipelines are now available t

SUBMITTER: Feierabend M 

PROVIDER: S-EPMC8634658 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature