Acute and Chronic Changes in Gene Expression After CMV DNAemia in Kidney Transplant Recipients.

ABSTRACT: Cytomegalovirus (CMV) viremia continues to cause significant morbidity and mortality in kidney transplant patients with clinical complications including organ rejection and death. Whole blood gene expression dynamics in CMV viremic patients from onset of DNAemia through convalescence has not been well studied to date in humans. To evaluate how CMV infection impacts whole blood leukocyte gene expression over time, we evaluated a matched cohort of 62 kidney transplant recipients with and without CMV DNAemia using blood samples collected at multiple time points during the 12-month period after transplant. While transcriptomic differences were minimal at baseline between DNAemic and non-DNAemic patients, hundreds of genes were differentially expressed at the long-term timepoint, including gene

SUBMITTER: Ahn R 

PROVIDER: S-EPMC8634678 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature