Delayed FDG PET Provides Superior Glioblastoma Conspicuity Compared to Conventional Image Timing.

ABSTRACT: Background: Glioblastomas are malignant, often incurable brain tumors. Reliable discrimination between recurrent disease and treatment changes is a significant challenge. Prior work has suggested glioblastoma FDG PET conspicuity is improved at delayed time points vs. conventional imaging times. This study aimed to determine the ideal FDG imaging time point in a population of untreated glioblastomas in preparation for future trials involving the non-invasive assessment of true progression vs. pseudoprogression in glioblastoma. Methods: Sixteen pre-treatment adults with suspected glioblastoma received FDG PET at 1, 5, and 8 h post-FDG injection within the 3 days prior to surgery. Maximum standard uptake values were measured at each timepoint for the central enhancing component

SUBMITTER: Johnson JM 

PROVIDER: S-EPMC8635110 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature