Comprehensive Metabolomics Study in Children With Graves' Disease.

ABSTRACT:

Objective

Graves' disease (GD) related hyperthyroidism (HT) has profound effects on metabolic activity and metabolism of macromolecules affecting energy homeostasis. In this study, we aimed to get a comprehensive understanding of the metabolic changes and their clinical relevance in GD children.

Methods

We investigated serum substances from 30 newly diagnosed GD children and 30 age- and gender-matched healthy controls. We explored the metabolomics using ultra-high-performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UHPLC-QTOF/MS) analysis, and then analyzed the metabolomic data via multivariate statistical analysis.

Results

By untargeted metabolomic analysis, a total of 730 metabolites were identified in all participants, among which

SUBMITTER: Xia Q 

PROVIDER: S-EPMC8635134 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature