Proteomic Studies on the Mechanism of Myostatin Regulating Cattle Skeletal Muscle Development.

ABSTRACT: Myostatin (MSTN) is an important negative regulator of muscle growth and development. In this study, we performed comparatively the proteomics analyses of gluteus tissues from MSTN^+/- Mongolian cattle (MG.MSTN^+/-) and wild type Mongolian cattle (MG.WT) using a shotgun-based tandem mass tag (TMT) 6-plex labeling method to investigate the regulation mechanism of MSTN on the growth and development of bovine skeletal muscle. A total of 1,950 proteins were identified in MG.MSTN^+/- and MG.WT. Compared with MG.WT cattle, a total of 320 differentially expressed proteins were identified in MG.MSTN cattle, including 245 up-regulated differentially expressed proteins and 75 down-regulated differentially expressed proteins. Bioinformatics analysis showed that knockdown

SUBMITTER: Sheng H 

PROVIDER: S-EPMC8635237 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature