VDR Signaling via the Enzyme NAT2 Inhibits Colorectal Cancer Progression.

ABSTRACT: Recent epidemiological and preclinical evidence indicates that vitamin D₃ inhibits colorectal cancer (CRC) progression, but the mechanism has not been completely elucidated. This study was designed to determine the protective effects of vitamin D₃ and identify crucial targets and regulatory mechanisms in CRC. First, we confirmed that 1,25(OH)₂D₃, the active form of vitamin D₃, suppressed the aggressive phenotype of CRC in vitro and in vivo. Based on a network pharmacological analysis, N-acetyltransferase 2 (NAT2) was identified as a potential target of vitamin D₃ against CRC. Clinical data of CRC patients from our hospital and bioinformatics analysis by online databases indicated that NAT2 was downregulated in

SUBMITTER: Zhu C 

PROVIDER: S-EPMC8635240 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature