Why do African-American men face higher risks for lethal prostate cancer?

ABSTRACT:

Purpose of review

African-American men in the USA have a higher incidence of and mortality from prostate cancer (PCa), with a longstanding debate about the cause for these worse outcomes. This review examines differences in tumour biology and socioeconomics for African-American and Non-Hispanic White (NHW) men to answer the question 'why AA men face higher risks for lethal PCa' and draw a management consensus to redress the imbalance.

Recent findings

Recent evidence from over the past 2 years suggests the reasons why African-American men face a higher risk of lethal PCa are multifactorial, with contributions from differences in tumour biology as well as socioeconomic and healthcare access factors. Regarding tumour biology, genomic and transcriptome profiling suggests African

SUBMITTER: Nair SS 

PROVIDER: S-EPMC8635247 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature