Insights into the molecular landscape of osteoarthritis in human tissues.

ABSTRACT:

Purpose of review

To provide an overview of recent developments in the field of osteoarthritis research with a focus on insights gleaned from the application of different -omic technologies.

Recent findings

We searched for osteoarthritis-relevant studies focusing on transcriptomics, epigenomics, proteomics and metabolomics, published since November of 2019. Study designs showed a trend towards characterizing the genomic profile of osteoarthritis-relevant tissues with high resolution, for example either by using single-cell technologies or by considering several -omic levels and disease stages.

Summary

Multitissue interactions (cartilage-subchondral bone; cartilage-synovium) are prevalent in the pathophysiology of osteoarthritis, which is characterized by substantial m

SUBMITTER: Katsoula G 

PROVIDER: S-EPMC8635257 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature