A growth factor-expressing macrophage subpopulation orchestrates regenerative inflammation via GDF-15.

ABSTRACT: Muscle regeneration is the result of the concerted action of multiple cell types driven by the temporarily controlled phenotype switches of infiltrating monocyte-derived macrophages. Pro-inflammatory macrophages transition into a phenotype that drives tissue repair through the production of effectors such as growth factors. This orchestrated sequence of regenerative inflammatory events, which we termed regeneration-promoting program (RPP), is essential for proper repair. However, it is not well understood how specialized repair-macrophage identity develops in the RPP at the transcriptional level and how induced macrophage-derived factors coordinate tissue repair. Gene expression kinetics-based clustering of blood circulating Ly6Chigh, infiltrating inflammatory Ly6Chigh, and reparative Ly6C

SUBMITTER: Patsalos A 

PROVIDER: S-EPMC8635277 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature