Autocrine inhibition by a glutamate-gated chloride channel mediates presynaptic homeostatic depression.
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ABSTRACT:
SUBMITTER: Li X
PROVIDER: S-EPMC8635443 | biostudies-literature | 2021 Dec
REPOSITORIES: biostudies-literature
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Autocrine inhibition by a glutamate-gated chloride channel mediates presynaptic homeostatic depression.
Li Xiling X Chien Chun C Han Yifu Y Sun Zihan Z Chen Xun X Dickman Dion D
Science advances 20211201 49
Homeostatic modulation of presynaptic neurotransmitter release is a fundamental form of plasticity that stabilizes neural activity, where presynaptic homeostatic depression (PHD) can adaptively diminish synaptic strength. PHD has been proposed to operate through an autocrine mechanism to homeostatically depress release probability in response to excess glutamate release at the <i>Drosophila</i> neuromuscular junction. This model implies the existence of a presynaptic glutamate autoreceptor. We s ...[more]
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