Autocrine inhibition by a glutamate-gated chloride channel mediates presynaptic homeostatic depression.

ABSTRACT: Homeostatic modulation of presynaptic neurotransmitter release is a fundamental form of plasticity that stabilizes neural activity, where presynaptic homeostatic depression (PHD) can adaptively diminish synaptic strength. PHD has been proposed to operate through an autocrine mechanism to homeostatically depress release probability in response to excess glutamate release at the Drosophila neuromuscular junction. This model implies the existence of a presynaptic glutamate autoreceptor. We systematically screened all neuronal glutamate receptors in the fly genome and identified the glutamate-gated chloride channel (GluClα) to be required for the expression of PHD. Pharmacological, genetic, and Ca²⁺ imaging experiments demonstrate that GluClα acts locally at axonal ter

SUBMITTER: Li X 

PROVIDER: S-EPMC8635443 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature