RNA-Binding Protein Expression Alters Upon Differentiation of Human B Cells and T Cells.

ABSTRACT: B cells and T cells are key players in the defence against infections and malignancies. To exert their function, B cells and T cells differentiate into effector and memory cells. Tight regulation of these differentiation processes is key to prevent their malfunction, which can result in life-threatening disease. Lymphocyte differentiation relies on the appropriate timing and dosage of regulatory molecules, and post-transcriptional gene regulation (PTR) is a key player herein. PTR includes the regulation through RNA-binding proteins (RBPs), which control the fate of RNA and its translation into proteins. To date, a comprehensive overview of the RBP expression throughout lymphocyte differentiation is lacking. Using transcriptome and proteome analyses, we here catalogued the RBP expression fo

SUBMITTER: Zandhuis ND 

PROVIDER: S-EPMC8635512 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature