Mutation in Irf8 Gene (Irf8^R294C ) Impairs Type I IFN-Mediated Antiviral Immune Response by Murine pDCs.

ABSTRACT: Plasmacytoid dendritic cells (pDCs) are the key producers of type I interferons (IFNs), thus playing a central role in initiating antiviral immune response. Besides robust type I IFN production, pDCs also act as antigen presenting cells post immunogenic stimulation. Transcription factor Irf8 is indispensable for the development of both pDC and cDC1 subset. However, the mechanism underlying the differential regulation by IRF8 in cDC1- and pDC-specific genomic architecture of developmental pathways still remains to be fully elucidated. Previous studies indicated that the Irf8^R294C mutation specifically abrogates development of cDC1 without affecting that of pDC. In the present study using RNA-seq based approach, we have found that though the point mutation

SUBMITTER: Das A 

PROVIDER: S-EPMC8635750 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature