Effectiveness and Toxicity of Fractionated Proton Beam Radiotherapy for Cranial Nerve Schwannoma Unsuitable for Stereotactic Radiosurgery.

ABSTRACT:

Purpose

In this benign tumor entity, preservation of cranial nerve function is of special importance. Due to its advantageous physical properties, proton beam radiotherapy (PRT) is a promising approach that spares healthy tissue. Could PRT go along with satisfactory preservation rates for cranial nerve function without compromising tumor control in patients with cranial nerve schwannoma unsuitable for stereotactic radiosurgery?

Methods

We analyzed 45 patients with cranial nerve schwannomas who underwent PRT between 2012 and 2020 at our institution. Response assessment was performed by MRI according to RECIST 1.1, and toxicity was graded following CTCAE 5.0.

Results

The most common schwannoma origin was the vestibulocochlear nerve with 82.2%, followed by the trigeminal

SUBMITTER: Eichkorn T 

PROVIDER: S-EPMC8635775 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature