Biomarkers of kidney function and cognitive ability: A Mendelian randomization study.

ABSTRACT:

Background

Estimated glomerular filtration rate (eGFR), albuminuria and serum uric acid (SUA) are markers of kidney function that have been associated with cognitive ability. However, whether these associations are causal is unclear.

Methods

We performed one-sample Mendelian randomization (MR) to estimate the effects of kidney function markers on cognitive performance using data from the UK Biobank. Polygenic scores for SUA, urine albumin to creatinine ratio (ACR), estimated glomerular filtration rate based on serum creatinine (eGFRcre) and serum cystatin C (eGFRcys) were used as instrumental variables, and cognitive function outcomes included tests of verbal-numeric reasoning, reaction time, visual memory, and numeric memory.

Results

We found no evidence of a causal

SUBMITTER: Richard EL 

PROVIDER: S-EPMC8635776 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature