Metabolomic Profiles of Plasma Retinol-Associated Dyslipidemia in Men and Women.

ABSTRACT: Background and Aims: Studies of both animals and humans show that a high intake of vitamin A is associated with a lower risk of dyslipidemia. However, an association of plasma retinol levels with dyslipidemia is unclear. Therefore, the aim of this study is to investigate an association between plasma retinol and dyslipidemia and to identify related metabolites and pathways in the general population. Methods: We included 250 participants aged 20-80 years from the Wellness Living Laboratory (WELL) China cohort. Associations between plasma retinol levels and dyslipidemia were analyzed using adjusted logistic models. Related metabolites were identified using ANCOVA, adjusted for the false discovery rate (FDR) and used for pathway analyses. Because there are sex differences in pla

SUBMITTER: Wang N 

PROVIDER: S-EPMC8635783 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature