Patterns of Insulin Secretion During First-Phase Insulin Secretion in Normal Chinese Adults.

ABSTRACT:

Background

The increase in diabetes worldwide is alarming. Decreased acute insulin response to intravenous glucose tolerance test (IVGTT) during first-phase insulin secretion (FPIS) is a characteristic of diabetes. However, knowledge of the insulin secretion characteristics identified by different time to glucose peak in subjects with different metabolic state is sparse.

Aims

This study aimed to find different patterns of FPIS in subjects with normal glucose tolerance (NGT) and analyzed the relationship between insulin secretion patterns and the risk for development of type 2 diabetes mellitus (T2DM).

Methods

A total of 126 subjects were divided into three groups during a 10-min IVGTT, including NGT with time to glucose peak after 3 min (G1, n = 21), NGT with time to

SUBMITTER: Yuan T 

PROVIDER: S-EPMC8635794 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature