Potential Association Between Dietary Fibre and Humoral Response to the Seasonal Influenza Vaccine.

ABSTRACT: Influenza vaccination is an effective public health measure to reduce the risk of influenza illness, particularly when the vaccine is well matched to circulating strains. Notwithstanding, the efficacy of influenza vaccination varies greatly among vaccinees due to largely unknown immunological determinants, thereby dampening population-wide protection. Here, we report that dietary fibre may play a significant role in humoral vaccine responses. We found dietary fibre intake and the abundance of fibre-fermenting intestinal bacteria to be positively correlated with humoral influenza vaccine-specific immune responses in human vaccinees, albeit without reaching statistical significance. Importantly, this correlation was largely driven by first-time vaccinees; prior influenza vaccination negative

SUBMITTER: Cait A 

PROVIDER: S-EPMC8635806 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature