Elderly Patients with Mild Cognitive Impairment Exhibit Altered Gut Microbiota Profiles.

ABSTRACT:

Background

As a transitional state between normal aging and Alzheimer's disease (AD), mild cognitive impairment (MCI) is characterized by a worse cognitive decline than that of natural aging. The association between AD and gut microbiota has been reported in a number of studies; however, microbial research regarding MCI remains limited.

Methods

This study examined 48 participants, of whom 22 were MCI cases and 26 were normal control cases. Fecal samples were collected for 16S ribosomal RNA (rRNA) quantitative arrays and bioinformatics analysis.

Results

A principal coordinates analysis (PCoA) and nonmetric multidimensional scaling (NMDS) both demonstrated that the microbial composition of participants with MCI deviated from that of healthy control participants. Multipl

SUBMITTER: Pan Q 

PROVIDER: S-EPMC8635943 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature