LTF Regulates the Immune Microenvironment of Prostate Cancer Through JAK/STAT3 Pathway.

ABSTRACT:

Background

The study of the immune microenvironment in prostate cancer (PRAD) has brought new opportunities for the current traditional treatment regimens. Therefore, our goal is to develop a universal immunodiagnostic marker to improve patient survival.

Methods

Bioinformatics analysis: We collected 591 samples from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) cohorts and evaluated the abundance and distribution of immune cell members in the PRAD expression profile matrix in the mixed cell population by CIBERSORT, ESTIMATE, single-sample gene set enrichment analysis (ssGSEA), and other methods. The target genes related to PRAD immune microenvironment and tumor mutation load were obtained by overlap analysis and verified by pan-cancer analysis. Cell experi

SUBMITTER: Zhao Q 

PROVIDER: S-EPMC8635998 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature