Identification and validation of an individualized prognostic signature of lung squamous cell carcinoma based on ferroptosis-related genes.

ABSTRACT:

Background

Lung squamous cell carcinoma (LUSC), one of the main pathological types of lung cancer, has led to consequential socioeconomic burden. Ferroptosis is an iron-dependent form of cell death process with potentials for therapeutic target in various kinds of tumors. However, whether ferroptosis-related genes (FRGs) are associated with the prognosis of LUSC patients is still unclear. The aim of this study was to establish a FRGs-based signature which could stratify patients with LUSC.

Methods

The RNA sequencing profiles and corresponding clinical data of LUSC patients were retrieved from The Cancer Genome Atlas (TCGA) database and Gene Expression Omnibus (GEO) dataset. A FRG-based signature was developed using the TCGA-LUSC cohort and validated in the GEO cohort. Gene s

SUBMITTER: Diao X 

PROVIDER: S-EPMC8636213 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature