In patients with heart failure, enhanced ventilatory response to exercise is associated with severe obstructive sleep apnea.

ABSTRACT:

Study objectives

Patients with congestive heart failure (CHF) frequently exhibit an elevated ratio of minute ventilation over CO₂ output (VE/VCO₂ slope) while undergoing exercise tests. One of the factors contributing to this elevated slope is an increased chemosensitivity to CO₂ in that this slope significantly correlates with the slope of the ventilatory response to CO₂ rebreathing at rest. A previous study in patients with CHF and central sleep apnea showed that the highest VE/VCO₂ slope during exercise was associated with the most severe central sleep apnea. In the current study, we tested the hypothesis that in patients with CHF and obstructive sleep apnea (OSA), the highest VE/VCO₂ slope is also associated with

SUBMITTER: Bittencourt L 

PROVIDER: S-EPMC8636352 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature