Sex differences in treatment patterns in cystic fibrosis pulmonary exacerbations.

ABSTRACT:

Background

Females with cystic fibrosis (CF) have been shown to have worse pulmonary exacerbation (PEx) related outcomes compared to males. However, it is unknown if sex differences in treatment patterns are contributing to these outcomes. Thus, we sought to explore sex differences in treatment patterns in the Standardized Treatment of Pulmonary Exacerbations (STOP) cohort.

Methods

Data for 220 participants from the STOP cohort were analyzed. Multivariable regression models were used to assess if female sex was associated with duration of treatment with IV antibiotics and inpatient length of stay. Secondary outcomes included antibiotic selection, adjunctive therapies, mean FEV1pp and CFRSD-CRISS respiratory symptom scores at the four study assessments.

Results

In our

SUBMITTER: Montemayor K 

PROVIDER: S-EPMC8636543 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature