Senolytic effects of quercetin in an in vitro model of pre-adipocytes and adipocytes induced senescence.

ABSTRACT: The dysfunction of adipose tissue with aging and the accumulation of senescent cells has been implicated in the pathophysiology of chronic diseases. Recently interventions capable of reducing the burden of senescent cells and in particular the identification of a new class of drugs termed senolytics have been object of extensive investigation. We used an in vitro model of induced senescence by treating both pre-adipocytes as well as mature adipocytes with hydrogen peroxide (H₂O₂) at a sub-lethal concentration for 3 h for three consecutive days, and hereafter with 20 uM quercetin at a dose that in preliminary experiments resulted to be senolytic without cytotoxicity. H₂O₂ treated pre-adipocytes and adipocytes showed typical senescence-associated f

SUBMITTER: Zoico E 

PROVIDER: S-EPMC8636588 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature