Pan-cancer analysis of non-oncogene addiction to DNA repair.

ABSTRACT: Cancer cells usually depend on the aberrant function of one or few driver genes to initiate and promote their malignancy, an attribute known as oncogene addiction. However, cancer cells might become dependent on the normal cellular functions of certain genes that are not oncogenes but ensure cell survival (non-oncogene addiction). The downregulation or silencing of DNA repair genes and the consequent genetic and epigenetic instability is key to promote malignancy, but the activation of the DNA-damage response (DDR) has been shown to become a type of non-oncogene addiction that critically supports tumour survival. In the present study, a systematic evaluation of DNA repair addiction at the pan-cancer level was performed using data derived from The Cancer Dependency Map and The Cancer Genome

SUBMITTER: Bermudez-Guzman L 

PROVIDER: S-EPMC8636604 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature