Siderophore-mediated zinc acquisition enhances enterobacterial colonization of the inflamed gut.
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ABSTRACT:
SUBMITTER: Behnsen J
PROVIDER: S-EPMC8636617 | biostudies-literature | 2021 Dec
REPOSITORIES: biostudies-literature
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Siderophore-mediated zinc acquisition enhances enterobacterial colonization of the inflamed gut.
Behnsen Judith J Zhi Hui H Aron Allegra T AT Subramanian Vivekanandan V Santus William W Lee Michael H MH Gerner Romana R RR Petras Daniel D Liu Janet Z JZ Green Keith D KD Price Sarah L SL Camacho Jose J Hillman Hannah H Tjokrosurjo Joshua J Montaldo Nicola P NP Hoover Evelyn M EM Treacy-Abarca Sean S Gilston Benjamin A BA Skaar Eric P EP Chazin Walter J WJ Garneau-Tsodikova Sylvie S Lawrenz Matthew B MB Perry Robert D RD Nuccio Sean-Paul SP Dorrestein Pieter C PC Raffatellu Manuela M
Nature communications 20211201 1
Zinc is an essential cofactor for bacterial metabolism, and many Enterobacteriaceae express the zinc transporters ZnuABC and ZupT to acquire this metal in the host. However, the probiotic bacterium Escherichia coli Nissle 1917 (or "Nissle") exhibits appreciable growth in zinc-limited media even when these transporters are deleted. Here, we show that Nissle utilizes the siderophore yersiniabactin as a zincophore, enabling Nissle to grow in zinc-limited media, to tolerate calprotectin-mediated zin ...[more]
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