Predicting the Prognosis of Esophageal Adenocarcinoma by a Pyroptosis-Related Gene Signature.

ABSTRACT: Esophageal adenocarcinoma (EAC) is a highly malignant type of digestive tract cancers with a poor prognosis despite therapeutic advances. Pyroptosis is an inflammatory form of programmed cell death, whereas the role of pyroptosis in EAC remains largely unknown. Herein, we identified a pyroptosis-related five-gene signature that was significantly correlated with the survival of EAC patients in The Cancer Genome Atlas (TCGA) cohort and an independent validation dataset. In addition, a nomogram based on the signature was constructed with novel prognostic values. Moreover, the downregulation of GSDMB within the signature is notably correlated with enhanced DNA methylation. The pyroptosis-related signature might be related to the immune response and regulation of the tumor microenvironme

SUBMITTER: Zeng R 

PROVIDER: S-EPMC8637127 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature