Treatment plan comparison of proton vs photon radiotherapy for lower-grade gliomas.

ABSTRACT:

Background and purpose

Patients with lower-grade gliomas are long-term survivors after radiotherapy and may benefit from the reduced dose to normal tissue achievable with proton therapy. Here, we aimed to quantify differences in dose to the uninvolved brain and contralateral hippocampus and compare the risk of radiation-induced secondary cancer for photon and proton plans for lower-grade glioma patients.

Materials and methods

Twenty-three patients were included in this in-silico planning comparative study and had photon and proton plans calculated (50.4 Gy(RBE = 1.1), 28 Fx) applying similar dose constraints to the target and organs at risk. Automatically calculated photon plans were generated with a 3 mm margin from clinical target volume (CTV) to planning target volume. Ma

SUBMITTER: Byskov CS 

PROVIDER: S-EPMC8637131 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature