Novel Optics-Based Approaches for Cardiac Electrophysiology: A Review.

ABSTRACT: Optical techniques for recording and manipulating cellular electrophysiology have advanced rapidly in just a few decades. These developments allow for the analysis of cardiac cellular dynamics at multiple scales while largely overcoming the drawbacks associated with the use of electrodes. The recent advent of optogenetics opens up new possibilities for regional and tissue-level electrophysiological control and hold promise for future novel clinical applications. This article, which emerged from the international NOTICE workshop in 2018, reviews the state-of-the-art optical techniques used for cardiac electrophysiological research and the underlying biophysics. The design and performance of optical reporters and optogenetic actuators are reviewed along with limitations of current probes. Th

SUBMITTER: Mullenbroich MC 

PROVIDER: S-EPMC8637189 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature