Exercise-Induced Plasma Metabolomic Profiles in Patients With Peripheral Arterial Disease.

ABSTRACT: Aim: A better knowledge of the biological consequences in the blood of these exercise-induced ischemic events in lower extremity artery disease (LEAD) may improve the prospects of disease management. We explored the preminus postexercise metabolomic difference in 39 patients with LEAD referred for a treadmill oximetry test [transcutaneous oximetry (TcPO₂)]. Methods: Ischemia was estimated through the sum of decrease from rest of oxygen pressure (DROPs) (limb TcPO₂ changes minus chest TcPO₂ changes) at buttocks, thighs, and calves regions. Targeted metabolomic analyses measuring 188 metabolites were performed on a few microliters blood samples taken at the earlobe at rest and 3 min after exercise. Results: Maximum walking distance (MWD)

SUBMITTER: Sempore WY 

PROVIDER: S-EPMC8637284 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature