Performance status and trial site-level factors are associated with missing data in palliative care trials: An individual participant-level data analysis of 10 phase 3 trials.

ABSTRACT:

Background

Missing data compromise the internal and external validity of trial findings, however there is limited evidence on how best to reduce missing data in palliative care trials.

Aim

To assess the association between participant and site level factors and missing data in palliative care trials.

Design and setting

Individual participant-level data analysis of 10 phase 3 palliative care trials using multi-level cross-classified models.

Results

Participants with missing data at the previous time-point and poorer performance status were more likely to have missing data for the primary outcome and quality of life outcomes, at the primary follow-up point and end of follow-up. At the end of follow-up, the number of site randomisations and number of study site pe

SUBMITTER: Hussain JA 

PROVIDER: S-EPMC8637362 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature