Metabolomic Analysis of Coronary Heart Disease in an African American Cohort From the Jackson Heart Study.

ABSTRACT:

Importance

African American individuals have disproportionate rates of coronary heart disease (CHD) but lower levels of coronary artery calcium (CAC), a marker of subclinical CHD, than non-Hispanic White individuals. African American individuals may have distinct metabolite profiles associated with incident CHD risk compared with non-Hispanic White individuals, and examination of these differences could highlight important processes that differ between them.

Objectives

To identify novel biomarkers of incident CHD and CAC among African American individuals and to replicate incident CHD findings in a multiethnic cohort.

Design, setting, and participants

This analysis targeted plasma metabolomic profiling of 2346 participants in the Jackson Heart Study (JHS), a prospecti

SUBMITTER: Cruz DE 

PROVIDER: S-EPMC8637385 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature