Photobiomodulation does not influence maturation and mildly improves functional healing of mouse achilles tendons.

ABSTRACT: Tendon rupture can occur at any age and is commonly treated nonoperatively, yet can result in persisting symptoms. Thus, a need exists to improve nonoperative treatments of injured tendons. Photobiomodulation (PBM) therapy has shown promise in the clinic and is hypothesized to stimulate mitochondrial-related metabolism and improve healing. However, the effect of PBM therapy on mitochondrial function during tendon maturation and healing are unknown, and its effect on tendon structure and function remain unclear. In this study, near-infrared light (980:810 nm blend, 2.5 J/cm² ) was applied at low (30 mW/cm² ) or high (300 mW/cm² ) irradiance to unilateral Achilles tendons of CD-1 mice during postnatal growth (maturation) as well as adult mice with bilateral A

SUBMITTER: Locke RC 

PROVIDER: S-EPMC8637462 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature