Positive Association Between Plasma Aldosterone Concentration and White Matter Lesions in Patients With Hypertension.

ABSTRACT:

Background and objective

White matter lesions (WMLs) are imaging changes in MRI of cerebral small vessel disease associated with vascular risk factors, increasing the risk of dementia, depression, and stroke. Aldosterone (ALD) or activation of mineralocorticoid receptor (MR) causes cerebrovascular injury in a mouse model. We aimed to analyze the relationship between ALD and WMLs in a population with hypertension.

Methods

We conducted a retrospective review of all patients screened for causes of secondary hypertension. We enrolled 547 patients with WMLs and matched these to controls without WMLs at a 1:1 ratio. White matter lesion load was assessed by using a modified Scheltens' scale.

Results

Among the analytic sample (N = 1,094) with ages ranging from 30 to 64 years,

SUBMITTER: Yuan Y 

PROVIDER: S-EPMC8637536 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature