Targeted and Enhanced Antimicrobial Inhibition of Mesoporous ZnO-Ag₂O/Ag, ZnO-CuO, and ZnO-SnO₂ Composite Nanoparticles.

ABSTRACT: In this work, mesoporous (pore size below 4 nm) composite nanoparticles of ZnO-Ag₂O/Ag, ZnO-CuO, and ZnO-SnO₂ of size d ≤ 10 nm (dia.) have been synthesized through the in situ solvochemical reduction method using NaBH₄. These composite nanoparticles exhibited excellent killing efficacy against Gram-positive/negative bacterial and fungal strains even at a very low dose of 0.010 μg/mL. Additionally, by applying the in silico docking approach, the nanoparticles and microorganism-specific targeted proteins and their interactions have been identified to explain the best anti-bacterial/anti-fungal activities of these composites. For this purpose, the virulence and resistance causing target proteins such as PqsR, RstA, FosA</

SUBMITTER: Pandey M 

PROVIDER: S-EPMC8637601 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature