Can the SARS-CoV-2 Spike Protein Bind Integrins Independent of the RGD Sequence?

ABSTRACT: The RGD motif in the Severe Acute Syndrome Coronavirus 2 (SARS-CoV-2) spike protein has been predicted to bind RGD-recognizing integrins. Recent studies have shown that the spike protein does, indeed, interact with α_Vβ₃ and α₅β₁ integrins, both of which bind to RGD-containing ligands. However, computational studies have suggested that binding between the spike RGD motif and integrins is not favourable, even when unfolding occurs after conformational changes induced by binding to the canonical host entry receptor, angiotensin-converting enzyme 2 (ACE2). Furthermore, non-RGD-binding integrins, such as α_x, have been suggested to interact with the SARS-CoV-2 spike protein. Other viral pathogens, such as rotaviruses, have been recorded to b

SUBMITTER: Beaudoin CA 

PROVIDER: S-EPMC8637727 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature