Insight into the Technical Qualification of the Sonocogreen CaO/Clinoptilolite Nanocomposite (CaO_(NP)/Clino) as an Advanced Delivery System for 5-Fluorouracil: Equilibrium and Cytotoxicity.

ABSTRACT: Clinoptilolite as a natural zeolite was integrated with green CaO nanoparticles forming the green nanocomposite CaO_(NP)/Clino. The CaO_(NP)/Clino composite was assessed as a potential carrier for 5-fluorouracil (5-FL) drug. The CaO_(NP)/Clino carrier achieved an enhanced 5-FL loading capacity of 305.3 mg/g as compared to 163 mg/g for pure clinoptilolite. The kinetics of the 5-FL loading follow the properties of the pseudo-first-order model, while the equilibrium results are related to the Langmuir isotherm. Therefore, the 5-FL loading processes occurred in the monolayer formed by homogeneous active loading receptors on the surface of the CaO_(NP)/Clino carrier. The Gaussian energy of the 5-FL loading reaction (9.2 KJ/mol) reflected the dominant effe

SUBMITTER: Abukhadra MR 

PROVIDER: S-EPMC8637967 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature