Investigations on Anticancer and Antimalarial Activities of Indole-Sulfonamide Derivatives and In Silico Studies.

ABSTRACT: A library of 44 indole-sulfonamide derivatives (1-44) were investigated for their cytotoxic activities against four cancer cell lines (i.e., HuCCA-1, HepG2, A549, and MOLT-3) and antimalarial effect. Most of the studied indoles exhibit anticancer activity against the MOLT-3 cell line, whereas only hydroxyl-containing bisindoles displayed anticancer activities against the other tested cancer cells as well as antimalarial effect. The most promising anticancer compounds were noted to be CF₃, Cl, and NO₂ derivatives of hydroxyl-bearing bisindoles (30, 31, and 36), while the most promising antimalarial compound was an OCH₃ derivative of non-hydroxyl-containing bisindole 11. Five quantitative structure-activity relationsh

SUBMITTER: Pingaew R 

PROVIDER: S-EPMC8638007 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature