Antibacterial Activity of Membrane-Permeabilizing Bactericidal Cyclodextrin Derivatives.

ABSTRACT: Antimicrobial peptides that act by disrupting bacterial membranes are attractive agents for treating drug-resistant bacteria. This study investigates a membrane-disrupting peptide mimic made of a cyclic oligosaccharide cyclodextrin scaffold that can be chemically polyfunctionalized. An antibacterial functional group on the peptide was simplified to an alkylamino group that combines cationic and hydrophobic moieties, the former to interact with the anionic bacterial membrane and the latter with the membrane interior. The cyclodextrins equipped with eight alkylamino groups on the molecules using a poly-click reaction exhibited antibacterial activity against Gram-positive and Gram-negative bacteria, including drug-resistant pathogens such as carbapenem-resistant Enterobacteriaceae. Sev

SUBMITTER: Yamamura H 

PROVIDER: S-EPMC8638021 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature