Endothelial-specific depletion of TGF-β signaling affects lymphatic function.

ABSTRACT:

Background

Transforming growth factor (TGF)-β is a multifunctional cytokine involved in cell differentiation, cell proliferation, and tissue homeostasis. Although TGF-β signaling is essential for maintaining blood vessel functions, little is known about the role of TGF-β in lymphatic homeostasis.

Methods

To delineate the role of TGF-β signaling in lymphatic vessels, TβRII^fl/fl mice were crossed with Prox1-Cre^ERT2 mice to generate TβRII^fl/fl; Prox1-Cre^ERT2 mice. The TβRII gene in the lymphatic endothelial cells (LECs) of the conditional knockout TβRII^iΔLEC mice was selectively deleted using tamoxifen. The effects of TβRII gene deletion on embryonic lymphangiogenesis, postnatal lymphatic structure and drainage function, tu

SUBMITTER: Fukasawa K 

PROVIDER: S-EPMC8638105 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature