Rare and potentially pathogenic variants in hydroxycarboxylic acid receptor genes identified in breast cancer cases.

ABSTRACT:

Background

Three genes clustered together on chromosome 12 comprise a group of hydroxycarboxylic acid receptors (HCARs): HCAR1, HCAR2, and HCAR3. These paralogous genes encode different G-protein coupled receptors responsible for detecting glycolytic metabolites and controlling fatty acid oxidation. Though better known for regulating lipid metabolism in adipocytes, more recently, HCARs have been functionally associated with breast cancer proliferation/survival; HCAR2 has been described as a tumor suppressor and HCAR1 and HCAR3 as oncogenes. Thus, we sought to identify germline variants in HCAR1, HCAR2, and HCAR3 that could potentially be associated with breast cancer risk.

Methods

Two different cohorts of breast cancer cases were investigated, the Alabama Hereditary Cancer C

SUBMITTER: McGuire Sams C 

PROVIDER: S-EPMC8638184 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature