Circulating noncoding RNAs as early predictive biomarkers in preeclampsia: a diagnostic meta-analysis.

ABSTRACT:

Background

We designed a meta-analysis to evaluate the clinical significance and efficacy of circulating noncoding RNAs (ncRNAs) in the early prediction of preeclampsia.

Methods

PubMed, Embase and the Cochrane Library were used to search for literature. The combined prediction performance was evaluated by calculating the area under the summary receiver operator characteristic (SROC) curve. The potential sources of heterogeneity were analysed by meta-regression analysis and subgroup analysis. All statistical analyses and mapping were performed by RevMan 5.3 and Stata 12.0.

Results

A total of 41 studies from 14 articles, including 557 preeclampsia patients and 842 controls, were included in our meta-analysis. All studies collected blood before onset. NcRNAs in blood per

SUBMITTER: Su S 

PROVIDER: S-EPMC8638188 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature