The role of the SLC6A3 3' UTR VNTR in nicotine effects on cognitive, affective, and motor function.

ABSTRACT:

Rationale

Nicotine has been widely studied for its pro-dopaminergic effects. However, at the behavioural level, past investigations have yielded heterogeneous results concerning effects on cognitive, affective, and motor outcomes, possibly linked to individual differences at the level of genetics. A candidate polymorphism is the 40-base-pair variable number of tandem repeats polymorphism (rs28363170) in the SLC6A3 gene coding for the dopamine transporter (DAT). The polymorphism has been associated with striatal DAT availability (9R-carriers > 10R-homozygotes), and 9R-carriers have been shown to react more strongly to dopamine agonistic pharmacological challenges than 10R-homozygotes.

Objectives

In this preregistered study, we hypothesized that 9R-carriers would be more respo

SUBMITTER: Schroder R 

PROVIDER: S-EPMC8638222 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature