Synthesis of Pertyolides A, B, and C: A Synthetic Procedure to C₁₇-Sesquiterpenoids and a Study of Their Phytotoxic Activity.

ABSTRACT: C₁₇-sesquiterpenoids are a group of natural products that have been recently discovered. These compounds have the peculiarity of lacking the α,β-methylene butyrolactone system, which is known to be quite relevant for many of the biological activities reported for sesquiterpene lactones. Unfortunately, the biological interest of C₁₇-sesquiterpenoids has not been studied in-depth, mainly due to the poor isolation yields in which they can be obtained from natural sources. Therefore, in order to allow a deeper study of these novel molecules, we have worked out a synthetic pathway that provides C₁₇-sesquiterpenoids in enough quantities from easily accessible sesquiterpene lactones to enable a more thorough investigation of their bioactivities. With this synthesi

SUBMITTER: Cardenas DM 

PROVIDER: S-EPMC8638260 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature