Ontology highlight
ABSTRACT:
SUBMITTER: Lam CKC
PROVIDER: S-EPMC8638314 | biostudies-literature | 2021 Dec
REPOSITORIES: biostudies-literature
Lam Chee Ka Candice CKC Truong Kevin K
Engineering in life sciences 20211029 12
Towards the goal of making 'smart' cell therapies, one that recognizes disease conditions (e.g. hypoxia) and then produces mitigating biologics, it is important to develop suitable promoters. Currently, hypoxia responsive promoters are composed of strongly repeated sequences containing hypoxia response elements upstream of a minimal core promoter. Unfortunately, such repeated sequences have inherent genomic instability that may compromise the long-term consistency of cell-based therapeutics. Thu ...[more]