Alterations of thyroid microbiota across different thyroid microhabitats in patients with thyroid carcinoma.

ABSTRACT:

Background

In recent years, the incidence rate of Thyroid carcinoma (TC) has been increasing worldwide. Thus, research on factors of TC carcinogenesis may promote TC prevention and decrease the incidence rate. There are several studies targeting the correlation between gut microbiota and thyroid disease. Carcinogenesis of several malignancies is influenced by microbiota. However, thyroid microbiome of TC has not been revealed. This study investigated thyroid microbiota in different TC microhabitats.

Methods

We performed 16s rRNA gene sequencing using tumor tissues and matched peritumor tissues from 30 patients with TC to characterize thyroid microbiota.

Results

The richness and diversity of thyroid microbiota were lower in TC tumor samples than in matched peritumor ti

SUBMITTER: Dai D 

PROVIDER: S-EPMC8638380 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature