IL-17 Receptor C Signaling Controls CD4⁺ T_H17 Immune Responses and Tissue Injury in Immune-Mediated Kidney Diseases.

ABSTRACT:

Background

IL-17A-producing CD4⁺ T helper (T_H17) cells play a critical role in autoimmune and chronic inflammatory diseases, such as crescentic GN. The proinflammatory effects of IL-17 are mediated by the activation of the IL-17RA/IL-17RC complex. Although the expression of these receptors on epithelial and endothelial cells is well characterized, the IL-17 receptor expression pattern and function on hematopoietic cells, e.g., CD4⁺ T cell subsets, remains to be elucidated.

Methods

Crescentic GN (nephrotoxic nephritis) was induced in IL-17A, IFNγ, and Foxp3 triple-reporter mice for sorting of renal CD4⁺ T cell subsets and subsequent single-cell RNA sequencing. Moreover, we generated T_H17 cell-specific IL-17R

SUBMITTER: Schmidt T 

PROVIDER: S-EPMC8638406 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature