Daily rhythms in gene expression of the human parasite Schistosoma mansoni.

ABSTRACT:

Background

The consequences of the earth's daily rotation have led to 24-h biological rhythms in most organisms. Even some parasites are known to have daily rhythms, which, when in synchrony with host rhythms, can optimise their fitness. Understanding these rhythms may enable the development of control strategies that take advantage of rhythmic vulnerabilities. Recent work on protozoan parasites has revealed 24-h rhythms in gene expression, drug sensitivity and the presence of an intrinsic circadian clock; however, similar studies on metazoan parasites are lacking. To address this, we investigated if a metazoan parasite has daily molecular oscillations, whether they reveal how these longer-lived organisms can survive host daily cycles over a lifespan of many years and if animal cir

SUBMITTER: Rawlinson KA 

PROVIDER: S-EPMC8638415 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature