Baseline [¹⁸F]GTP1 tau PET imaging is associated with subsequent cognitive decline in Alzheimer's disease.

ABSTRACT:

Background

The role and implementation of tau PET imaging for predicting subsequent cognitive decline in Alzheimer's disease (AD) remains uncertain. This study was designed to evaluate the relationship between baseline [¹⁸F]GTP1 tau PET and subsequent longitudinal change across multiple cognitive measures over 18 months.

Methods

Our analyses incorporated data from 67 participants, including cognitively normal controls (n = 10) and β-amyloid (Aβ)-positive individuals ([¹⁸F] florbetapir Aβ PET) with prodromal (n = 26), mild (n = 16), or moderate (n = 15) AD. Baseline measurements included cortical volume (MRI), tau burden ([¹⁸F]GTP1 tau PET), and cognitive assessments [Mini-Mental State Examination (MMSE), Clinical Dementia Rating (CDR), 13-ite

SUBMITTER: Teng E 

PROVIDER: S-EPMC8638526 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature